Lipase-catalyzed resolution of primary alcohol containing quaternary chiral carbon

✍ Scribed by Chan Seong Cheong; Dai Sig Im; Jiyoung Kim; In O Kim

• Book ID: 104633535
• Publisher: Springer Netherlands
• Year: 1996
• Tongue: English
• Weight: 279 KB
• Volume: 18
• Category: Article
• ISSN: 0141-5492
• DOI: 10.1007/bf00129346

✦ Synopsis

2-Cyano-2-phenyl-I-hexanol containing chiral quatemary carbon was resolved using a lipase. Among various reaction conditions, transesterification reaction (solvent; n-hexane, lipase; Candida cylindracea) gave high selectivity(20/80). Additionally, the selectivity could be improved( 13187) when pyridine( 1%) was used as an additive. The ratios of resolved alcohols were determined by GC and 'H-NMR analysis using Mosher's derivative.