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Lipase-Catalyzed Remote Kinetic Resolution of Quaternary Carbon-Containing Alcohols and Determination of Their Absolute Configuration.

✍ Scribed by Dai Sig Im; Chan Seong Cheong; So Ha Lee


Publisher
John Wiley and Sons
Year
2004
Weight
135 KB
Volume
35
Category
Article
ISSN
0931-7597

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Efficient Lipase-Catalyzed Kinetic Resol
✍ Oscar PΓ mies; Jan-E. BΓ€ckvall πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 87 KB πŸ‘ 1 views

Chemoenzymatic dynamic kinetic resolution of b-hydroxy nitriles 1 has been carried out using Candida antarctica lipase B and a ruthenium catalyst. The use of a hydrogen source to depress ketone formation in the dynamic kinetic resolution yields the corresponding acetates 2 in good yield and high ena