Chemoenzymatic dynamic kinetic resolution of b-hydroxy nitriles 1 has been carried out using Candida antarctica lipase B and a ruthenium catalyst. The use of a hydrogen source to depress ketone formation in the dynamic kinetic resolution yields the corresponding acetates 2 in good yield and high ena
✦ LIBER ✦
Efficient Lipase-Catalyzed Kinetic Resolution and Dynamic Kinetic Resolution of β-Hydroxy Nitriles. Correction of Absolute Configuration and Transformation to Chiral β-Hydroxy Acids and γ-Amino Alcohols.
✍ Scribed by Oscar Pamies; Jan-E. Baeckvall
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 344 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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