Efficient Lipase-Catalyzed Kinetic Resolution and Dynamic Kinetic Resolution of β-Hydroxy Nitriles. A Route to Useful Precursors for γ-Amino Alcohols

Efficient Lipase-Catalyzed Kinetic Resol

Efficient Lipase-Catalyzed Kinetic Resolution and Dynamic Kinetic Resolution of β-Hydroxy Nitriles. Correction of Absolute Configuration and Transformation to Chiral β-Hydroxy Acids and γ-Amino Alcohols

✍ Oscar Pàmies; Jan-E. Bäckvall 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 87 KB 👁 1 views

Chemoenzymatic dynamic kinetic resolution of b-hydroxy nitriles 1 has been carried out using Candida antarctica lipase B and a ruthenium catalyst. The use of a hydrogen source to depress ketone formation in the dynamic kinetic resolution yields the corresponding acetates 2 in good yield and high ena