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ChemInform Abstract: Efficient Lipase-Catalyzed Kinetic Resolution and Dynamic Kinetic Resolution of β-Hydroxy Nitriles. A Route to Useful Precursors for γ-Amino Alcohols.

✍ Scribed by Oscar Pamies; Jan-E. Baeckvall

Publisher
John Wiley and Sons
Year
2010
Weight
36 KB
Volume
32
Category
Article
ISSN
0931-7597

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Abstract

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Efficient Lipase-Catalyzed Kinetic Resol
Efficient Lipase-Catalyzed Kinetic Resolution and Dynamic Kinetic Resolution of β-Hydroxy Nitriles. Correction of Absolute Configuration and Transformation to Chiral β-Hydroxy Acids and γ-Amino Alcohols
✍ Oscar Pàmies; Jan-E. Bäckvall 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 87 KB 👁 1 views

Chemoenzymatic dynamic kinetic resolution of b-hydroxy nitriles 1 has been carried out using Candida antarctica lipase B and a ruthenium catalyst. The use of a hydrogen source to depress ketone formation in the dynamic kinetic resolution yields the corresponding acetates 2 in good yield and high ena