3-,4-Pyridyl and 4-quinolyl Grignard reagents were generated by the reaction of the corresponding phenyl sulfoxides with PhMgBr and give the adducts upon treatment with various aldehydes and ketones. The stereochemistry for the reaction
Ligand exchange reactions of aryl pyridyl sulfoxides with grignard reagents: Convenient preparation of 3- and 4-pyridyl grignard reagents and examination of the leaving abilities of pyridyl anions
โ Scribed by Tadao Shibutani; Hisashi Fujihara; Naomichi Furukawa; Shigeru Oae
- Book ID
- 118283722
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 916 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1042-7163
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๐ SIMILAR VOLUMES
Pyridyl Grignard reagents were prepared from the corresponding iodopyridine and EtMgBr. New cross coupling reactions of the Grignard reagents with azaheterocycles took place on the sulfinyl sulfur atom to afford biazaheteroaryls.
Substituted 2-methylsulfinyl pyridines react with Grignard reagents to afford 6,6'-disubstituted-2,2 '-bipyridines (substituents: MeS, Cl, Br, H) in fair yields. Recently, we have shown that the reaction of benzyl 2-pyridyl sulfoxide with Grignard reagents or organolithium reagents gives intramolecu