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A convenient preparation of bipyridines through ligand coupling reaction with a-sulfurane formed by treatment of methyl 2-pyridyl sulfoxide with grignard reagents

โœ Scribed by Tsutomu Kawai; Naomichi Furukawa; Shigeru Oae

Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
244 KB
Volume
25
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Substituted 2-methylsulfinyl pyridines react with Grignard reagents to afford 6,6'-disubstituted-2,2 '-bipyridines (substituents: MeS, Cl, Br, H) in fair yields. Recently, we have shown that the reaction of benzyl 2-pyridyl sulfoxide with Grignard reagents or organolithium reagents gives intramolecular ligand coupling products within a-sulfuranes formed incipiently upon nucleophilic

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