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Knockdown of amyloid precursor protein gene corrects altered intracellular Ca2+ signals in a cell line derived from the cerebral cortex of trisomy 16 mouse: An animal model of Down syndrome

✍ Scribed by Gonzalo Encina; Christian Arriagada; Patricia Opazo; Guillermo Rojas; Michelle de Saint Pierre; Ana María Cárdenas; Takeshi Shimahara; Juan Segura-Aguilar; Raúl Caviedes; Pablo Caviedes


Book ID
113747710
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
79 KB
Volume
99
Category
Article
ISSN
0928-4257

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Knockdown of amyloid precursor protein n
✍ Patricia Opazo; Katherine Saud; Michelle de Saint Pierre; Ana María Cárdenas; Da 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 307 KB

## Abstract We have generated immortal neuronal cell lines from normal and trisomy 16 (Ts16) mice, a model for Down syndrome (DS). Ts16 lines overexpress DS‐related genes (__App__, amyloid precursor protein; __Sod1__, Cu/Zn superoxide dismutase) and show altered cholinergic function (reduced cholin