Altered Voltage Dependent Calcium Currents in a Neuronal Cell Line Derived From the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Down Syndrome
✍ Scribed by Mario A. Acuña, Ramón Pérez-Nuñez, Jorge Noriega, Ana María Cárdenas, Juan Bacigalupo, Ricardo Delgado, Christian Arriagada, Juan Segura-Aguilar, Raúl Caviedes, Pablo Caviedes
- Book ID
- 113108104
- Publisher
- Springer-Verlag
- Year
- 2011
- Tongue
- English
- Weight
- 551 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1029-8428
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## Abstract We have generated immortal neuronal cell lines from normal and trisomy 16 (Ts16) mice, a model for Down syndrome (DS). Ts16 lines overexpress DS‐related genes (__App__, amyloid precursor protein; __Sod1__, Cu/Zn superoxide dismutase) and show altered cholinergic function (reduced cholin
## Abstract We report the establishment of continuously growing cell lines from spinal cords of normal and trisomy 16 fetal mice. We show that both cell lines, named M4b (derived from a normal animal) and MTh (trisomic) possess neurological markers by immunohistochemistry (neuron specific enolase,