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Effect of the knockdown of amyloid precursor protein on intracellular calcium increases in a neuronal cell line derived from the cerebral cortex of a trisomy 16 mouse

✍ Scribed by Guillermo Rojas; Ana María Cárdenas; Paola Fernández-Olivares; Takeshi Shimahara; Juan Segura-Aguilar; Raúl Caviedes; Pablo Caviedes

Book ID
116459224
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
570 KB
Volume
209
Category
Article
ISSN
0014-4886

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Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of down syndrome
✍ Patricia Opazo; Katherine Saud; Michelle de Saint Pierre; Ana María Cárdenas; Da 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 307 KB

## Abstract We have generated immortal neuronal cell lines from normal and trisomy 16 (Ts16) mice, a model for Down syndrome (DS). Ts16 lines overexpress DS‐related genes (__App__, amyloid precursor protein; __Sod1__, Cu/Zn superoxide dismutase) and show altered cholinergic function (reduced cholin