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Endosomal abnormalities related to amyloid precursor protein in cholesterol treated cerebral cortex neuronal cells derived from trisomy 16 mice, an animal model of Down syndrome

✍ Scribed by Christian Arriagada; César Astorga; Illani Atwater; Eduardo Rojas; David Mears; Raúl Caviedes; Pablo Caviedes

Book ID
116769756
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
441 KB
Volume
423
Category
Article
ISSN
0304-3940

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## Abstract We have generated immortal neuronal cell lines from normal and trisomy 16 (Ts16) mice, a model for Down syndrome (DS). Ts16 lines overexpress DS‐related genes (__App__, amyloid precursor protein; __Sod1__, Cu/Zn superoxide dismutase) and show altered cholinergic function (reduced cholin