Kinetics and mechanisms of the aminolysis of N-hydroxysuccinimide esters in aqueous buffers
β Scribed by Cline, Gary W.; Hanna, Samir B.
- Book ID
- 118022981
- Publisher
- American Chemical Society
- Year
- 1988
- Tongue
- English
- Weight
- 539 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
Kinetic studies were carried out on the aminolysis reactions of substituted aliphatic esters in a variety of aprotic solvents. The reaction rate is strongly affected by inductive and steric effects of substituents in the acyl group, rising more than 10 4 -fold from cyanoacetate to trifluoroacetate.
Kinetic studies of the reactions of p-nitrophenyl N-phenylcarbamates with benzylamines were carried out in acetonitrile at 25β’0 Β°C. Second-order (k 2 ) and third-order (k 3 ) rate constants were observed for all the Y-substituted carbamates except for Y = m Οͺ Cl. The relatively large magnitude of X