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Irradiation induces G2/M cell cycle arrest and apoptosis in p53-deficient lymphoblastic leukemia cells without affecting Bcl-2 and Bax expression

✍ Scribed by Strasser-Wozak, Elisabeth MC; Hartmann, Bernd L; Geley, Stephan; Sgonc, Roswitha; Böck, Günther; Oliveira Dos Santos, Antonio J; Hattmannstorfer, Rosa; Wolf, Hugo; Pavelka, Margit; Kofler, Reinhard


Book ID
110015807
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
318 KB
Volume
5
Category
Article
ISSN
1350-9047

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## Abstract Methylxantine derivative, caffeine, is known to prevent the p53‐dependent apoptosis pathway via inhibition of ATM (ataxia telangiectasia mutated) kinase, which activates p53 by phosphorylation of the Ser‐15 residue. In contrast, it has been reported that caffeine induces p53‐mediated ap