The present Letter identified 2 0 -hydroxy-2,3,4 0 ,6 0 -tetramethoxychalcone (HTMC) as a potent in vitro cytotoxic agent with selective activity against cell lines derived from human lung cancer. In A549 lung adenocarcinoma cells, HTMC caused G1 phase cell-cycle arrest. HTMC treatment also led to a
β¦ LIBER β¦
P53 and p38 MAPK pathways are involved in MONCPT-induced cell cycle G2/M arrest in human non-small cell lung cancer A549
β Scribed by Chong Zhang; Hong Zhu; Xiaochun Yang; Jianshu Lou; Difeng Zhu; Wei lu; Qiaojun He; Bo Yang
- Publisher
- Springer-Verlag
- Year
- 2009
- Tongue
- English
- Weight
- 507 KB
- Volume
- 136
- Category
- Article
- ISSN
- 1432-1335
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## Abstract Berberine has been shown to have antiβcarcinogenic effects. Since p53 is the most commonly mutated tumor suppressor gene, and a lack of functional p53 is associated with an increased risk of cancer development, we examined the effects of berberine on p53βpositive and p53βdeficient nonβs