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Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma

✍ Scribed by Enyu Liu; Jing Wu; Weidong Cao; Jianning Zhang; Weiping Liu; Xiaofan Jiang; Xiang Zhang


Publisher
Springer US
Year
2007
Tongue
English
Weight
275 KB
Volume
85
Category
Article
ISSN
0167-594X

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## Abstract Methylxantine derivative, caffeine, is known to prevent the p53‐dependent apoptosis pathway via inhibition of ATM (ataxia telangiectasia mutated) kinase, which activates p53 by phosphorylation of the Ser‐15 residue. In contrast, it has been reported that caffeine induces p53‐mediated ap