Activation of the tumor suppressor protein p53 can lead to arrest in both G 1 and G 2 stages of the cell cycle and, in some cells, to apoptotic cell death. In this study, we showed that the p53 response to a chemotherapeutic drug, actinomycin D, was reversible in both normal and tumor cells, even wh
Introduction of p53 induces cell-cycle arrest in p53-deficient human medullary-thyroid-carcinoma cells
✍ Scribed by Juan A. Velasco; Diego L. Medina; Jesús Romero; M. Eugenia Mato; Pilar Santisteban
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- French
- Weight
- 484 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Zhi-Jiang Wu and carcinomatous ovarian cells. The apoptosis-related genes p53, bcl-2, and c- ## Qi-Rong Gao myc have important roles in the regulation of programmed cell death, and thus Gang Pei, Ph.D. may be involved in the process of the suspected PROG-induced apoptosis. ## METHODS. Antip
The role of the p53 protein in mediating G 1 and G 2 cell-cycle arrests after genotoxic insult has been clearly and reproducibly established in primary diploid fibroblasts, but data obtained from p53 wild-type (wt) cancer cell lines are inconsistent. Furthermore, a large proportion of human tumors h
Mutation of the p53 tumor suppressor gene has been demonstrated in a large proportion of human head and neck squamous cell carcinomas (HNSCCs) and has been assumed to play a role in the pathogenesis of these tumors, although no formal evidence of functional aberration has been demonstrated. In this
p53 mutations are found in about 70% of human cancers. In order to evaluate the role of these mutations in response to chemotherapeutic agents, it is important to distinguish between p53 response to DNA-damaging agents in normal and in tumour cells. Here, using normal human fibroblasts (NHFs), we sh