Chalcone HTMC causes in vitro selective cytotoxicity, cell-cycle G1 phase arrest through p53-dependent pathway in human lung adenocarcinoma A549 cells, and in vivo tumor growth suppression
✍ Scribed by Yerra Koteswara Rao; Te-Yu Kao; Jiunn-Liang Ko; Yew-Min Tzeng
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 680 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0960-894X
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✦ Synopsis
The present Letter identified 2 0 -hydroxy-2,3,4 0 ,6 0 -tetramethoxychalcone (HTMC) as a potent in vitro cytotoxic agent with selective activity against cell lines derived from human lung cancer. In A549 lung adenocarcinoma cells, HTMC caused G1 phase cell-cycle arrest. HTMC treatment also led to an inhibition of cell-cycle regulatory proteins phosphorylation of cdc2 (Tyr 15 and Tyr 161 ) and Rb (Ser 795 and Ser 807/811 ), which was accompanied by the accumulation of tumor suppresser genes p53 and p21. In addition, in vivo data demonstrated that HTMC act as a tumor growth suppressing agent.