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Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway

✍ Scribed by Mingji Xian; Keisuke Ito; Tomonori Nakazato; Takatsune Shimizu; Chien-Kang Chen; Kenji Yamato; Akira Murakami; Hajime Ohigashi; Yasuo Ikeda; Masahiro Kizaki

Book ID
108583789
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
504 KB
Volume
98
Category
Article
ISSN
1347-9032

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## Abstract Methylxantine derivative, caffeine, is known to prevent the p53‐dependent apoptosis pathway via inhibition of ATM (ataxia telangiectasia mutated) kinase, which activates p53 by phosphorylation of the Ser‐15 residue. In contrast, it has been reported that caffeine induces p53‐mediated ap