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IRF6 is a risk factor for nonsyndromic cleft lip in the Brazilian population

✍ Scribed by Luciano A. Brito; Camila F.S. Bassi; Cibele Masotti; Carolina Malcher; Kátia M. Rocha; David Schlesinger; Daniela F. Bueno; Lucas A. Cruz; Ligia K. Barbara; Débora R. Bertola; Diogo Meyer; Diogo Franco; Nivaldo Alonso; Maria Rita Passos-Bueno

Book ID
115549367
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
138 KB
Volume
158A
Category
Article
ISSN
1552-4825

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## Abstract ## Objectives/Hypothesis: Interferon regulatory factor 6 (__IRF6__), the gene that causes van der Woude syndrome (VWS), is a candidate gene for nonsyndromic cleft lip with or without cleft palate (NSCLP) because a number of studies have supported an association between NSCLP and single

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## Abstract **INTRODUCTION:** Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common of all birth defects. NSCL/P has a multifactorial etiology that includes both genetic and environmental factors. The __IRF6__ gene and three further susceptibility loci at 8q24, 10q2