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Interferon regulatory factor (IRF)-6 820 (G>A) polymorphism is not assiciated with nonsyndromic cleft lip and/or palate in korean population

โœ Scribed by Hyun Soo Park; Kun Woo Kim; Cha-Hui Lee; Soon-Sup Shim; Joong Shin Park; Jong Kwan Jun


Book ID
113431771
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
58 KB
Volume
195
Category
Article
ISSN
1097-6868

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## Abstract ## Objectives/Hypothesis: Interferon regulatory factor 6 (__IRF6__), the gene that causes van der Woude syndrome (VWS), is a candidate gene for nonsyndromic cleft lip with or without cleft palate (NSCLP) because a number of studies have supported an association between NSCLP and single

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## Abstract **INTRODUCTION:** Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common of all birth defects. NSCL/P has a multifactorial etiology that includes both genetic and environmental factors. The __IRF6__ gene and three further susceptibility loci at 8q24, 10q2