## Abstract **BACKGROUND:** Nonsyndromic cleft lip with or without cleft palate (NCL/P) is a common structural malformation with a complex and multifactorial etiology. It has been shown that maternal psychological stress in the periconceptional period can contribute to an increase in the risk of NC
Contribution of variants in and near the IRF6 gene to the risk of nonsyndromic cleft lip with or without cleft palate in a Malay population
β Scribed by Iman Salahshourifar; Wan Azman Wan Sulaiman; Bin Alwi Zilfalil; Ahmad Sukari Halim
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 249 KB
- Volume
- 155
- Category
- Article
- ISSN
- 1552-4825
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## Abstract ## BACKGROUND Cleft lip with or without cleft palate (CL/P) is one of the most common craniofacial malformations, with a complex and multifactorial etiology. Because of the genetic heterogeneity of facial clefts, the aim of this study was to investigate the contribution of previously r
## Abstract **INTRODUCTION:** Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common of all birth defects. NSCL/P has a multifactorial etiology that includes both genetic and environmental factors. The __IRF6__ gene and three further susceptibility loci at 8q24, 10q2
The identification of several putative susceptibility loci for nonsyndromic cleft lip with or without cleft palate (CL f P) has sparked a renewed interest in the genetics of this condition. However, prior to undertaking linkage studies for complex traits such as CL f P it is desirable to have some u