Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population

✍ Scribed by Adrianna Mostowska; Kamil K. Hozyasz; Piotr Wojcicki; Barbara Biedziak; Patrycja Paradowska; Pawel P. Jagodzinski

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 103 KB
• Volume: 88
• Category: Article
• ISSN: 1542-0752
• DOI: 10.1002/bdra.20687

✦ Synopsis

Abstract

BACKGROUND

Cleft lip with or without cleft palate (CL/P) is one of the most common craniofacial malformations, with a complex and multifactorial etiology. Because of the genetic heterogeneity of facial clefts, the aim of this study was to investigate the contribution of previously reported candidate genes and chromosomal loci to the risk of CL/P in the Polish population.

METHODS

We performed an analysis of 18 polymorphisms of FOXE1, IRF6, MSX1, PAX9, TBX10, FGF10, FGFR1, __TGF__α, TGF__β__3, SUMO1, and the chromosomal region 8q24 in a group of 175 patients with CL/P and a properly matched control group.

RESULTS

Highly significant results were observed for the IRF6 rs642961 variant and the 8q24 region's rs987525 (odds ratio [OR]~AG+AAvsGG~, 1.635; 95% confidence interval [CI], 1.153–2.319; p = 0.005; and OR~AC+AAvsCC~, 1.962; 95% CI, 1.382–2.785; p = 1.4 × 10^−4^, respectively). For rs987525, the results were also significant after correction for multiple comparisons. Borderline association with an increased risk of CL/P was also identified for the SUMO1 locus (rs2350350; OR~CGvsGG~, 1.580; 95% CI, 1.056–2.363; p = 0.025).

CONCLUSIONS

Our findings confirmed that genetic variants of IRF6 and the polymorphism located in the 8q24 gene desert are strongly involved in the etiology of facial clefts in the Polish population sample. Birth Defects Research (Part A), 2010. © 2010 Wiley‐Liss, Inc.