Nonsyndromic cleft lip with or without cleft palate (CL/P) is a common congenital malformation affecting about 1/1,000 caucasian infants. Although the familial clustering of CL/P has been studied thoroughly, estimation of recurrence risk for genetic counseling purposes can be difficult. A survey was
Role of the C677T polymorphism at theMTHFR gene on risk to nonsyndromic cleft lip with/without cleft palate: Results from a case-control study in Brazil
✍ Scribed by Gaspar, D. A.; Pavanello, R. C.; Zatz, M.; Passos-Bueno, M. R.; Andr�, M.; Steman, S.; Wyszynski, D. F.; Matiolli, S. R.
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 9 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0148-7299
- DOI
- 10.1002/(sici)1096-8628(19991119)87:2<197::aid-ajmg15>3.0.co;2-m
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Nonsyndromic cleft lip with or without cleft palate (NSCLP) is one of the most common human malformations with an average prevalence of 1 in 1,000 live births. The cause(s) of NSCLP remain unclear as the relative roles of genes, of the environment, and/or of chance alone are unknown. The purpose of