Linkage disequilibrium between IRF6 variants and nonsyndromic cleft lip/palate in the Chilean population
✍ Scribed by José Suazo; José Luis Santos; Lilian Jara; Rafael Blanco
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 53 KB
- Volume
- 146A
- Category
- Article
- ISSN
- 1552-4825
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## Abstract **INTRODUCTION:** Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common of all birth defects. NSCL/P has a multifactorial etiology that includes both genetic and environmental factors. The __IRF6__ gene and three further susceptibility loci at 8q24, 10q2
## Abstract ## BACKGROUND Cleft lip with or without cleft palate (CL/P) is one of the most common craniofacial malformations, with a complex and multifactorial etiology. Because of the genetic heterogeneity of facial clefts, the aim of this study was to investigate the contribution of previously r