✦ LIBER ✦

Interactions of metal ions with polynucleotides and related compounds. III. Degradation of polyribonucleotides by lanthanum ions,

✍ Scribed by Gunther L. Eichhorn; James J. Butzow

Publisher: Wiley (John Wiley & Sons)
Year: 1965
Tongue: English
Weight: 824 KB
Volume: 3
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.360030109

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✦ Synopsis

The polyrihonucleotides of adenylic, cytidylic, and uridylic acids are degraded in a 2-hr. period at 64°C. into low molecular weight oligoniicleot,ides and mononncleotides through the action of lanthanum ( 111) or other trivalent inner transition met,al ions. Polyinosinic arid is degraded somewhat more slowly. Cleavage of the polynucleotide chains orciirs at, the 5'-phosphate linkages. The 3'-mononucleotides produced require over 100 hr. of furt,her heating a t 64°C. to produce nucleoside and orthophosphate. The reaction beht-een lanthanum (111) and the polynucleoside involves one metal ion for every three nucleot,ide residues, with each metal ion apparently chelated to 2'- hydroxyl :$id a phosphate group and hound to only one polynucleotide chain.

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