Interaction of metal ions with polynucleotides and related compounds. IX. Unwinding and rewinding of poly(A + U) and poly(I + C) by copper(II) ions
✍ Scribed by Gunther L. Eichhorn; Edward Tarien
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1967
- Tongue
- English
- Weight
- 459 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0006-3525
No coin nor oath required. For personal study only.
✦ Synopsis
It is demonstrated that poly(A + U) and poly(1 + C) are both formed nnder low ionic strength conditions. Continuous variation studies indicate the formation of copper(I1) complexes of poly A, poly C, and poly I, but not of poly U. Copper(I1) in a I: 1 ratio to polynucleotide prevents the formation of poly(A + U) and brings about the dissociation of the poly(A + U ) complex prodiiced in the absence of the metal. Poly(1 + C ) is similarly dissociated by copper(I1) ions. The addition of sufficient, electrolyte reverses the copper(I1) induced dissociation of poly(1 + C). The effect of copper(I1) on ordered synthetic polynucleotides is thus very similar to its effect on DNA.