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Interaction of metal ions with polynucleotides and related compounds. XXII. Effect of divalent metal ions on the conformational changes of polyribonucleotides

✍ Scribed by Yong Ae Shin

Publisher: Wiley (John Wiley & Sons)
Year: 1973
Tongue: English
Weight: 918 KB
Volume: 12
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.1973.360121103

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✦ Synopsis

Abstract

Changes in the conformation of poly(G), poly(C), poly(U), and poly(I) in the presence of divalent metal ions Mg^2+^, Ca^2+^, Mn^2+^, Co^2+^, Ni^2+^, Cu^2+^, Cd^2+^, and Zn^2+^ have been measured by means of ORD and u.v. spectra. Mg^2+^ and Ca^2+^ ions stabilize helical structures of all the polynucleotides very effectively at concentrations several orders of magnitude lower than the effective concentration of Na^+^ion.

Cu^2+^ and Cd^2+^ destabilize the helical structure of polynucleotides to form random coils. Zn^2+^, Ni^2+^, Co^2+^, and Mn^2+^ions do not behave in such a clear‐cut manner: they selectively stabilize some ordered structures, while destabilizing others, depending on the ligand strength of the nucleotide base as well as the preferred conformation of that polynucleotide.

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