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Inhibition of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by β-carboline and indole derivatives

✍ Scribed by Naomi Eguchi; Yasuyoshi Watanabe; Kazuko Kawanishi; Yohei Hashimoto; Osamu Hayaishi

Book ID
115706327
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
644 KB
Volume
232
Category
Article
ISSN
0003-9861

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## Abstract The first and rate‐limiting step of the kynurenine pathway, in which tryptophan (Trp) is converted to __N__‐formylkynurenine is catalyzed by two heme‐containing proteins, Indoleamine 2,3‐dioxygenase (IDO), and Tryptophan 2,3‐dioxygenase (TDO). In mammals, TDO is found exclusively in liv