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Expression and localization of the tryptophan-degrading enzymes tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase-2 in the human placenta

✍ Scribed by Nikitina, Liudmila; Blaschitz, Astrid; Gauster, Martin; Besenböck, Carolin; Wadsack, Christian; Desoye, Gernot; Sedlmayr, Peter

Book ID
126841213
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
66 KB
Volume
35
Category
Article
ISSN
0143-4004

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## Abstract The first and rate‐limiting step of the kynurenine pathway, in which tryptophan (Trp) is converted to __N__‐formylkynurenine is catalyzed by two heme‐containing proteins, Indoleamine 2,3‐dioxygenase (IDO), and Tryptophan 2,3‐dioxygenase (TDO). In mammals, TDO is found exclusively in liv