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2,5-dihydro-L-phenylalanine: A competitive inhibitor of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase

โœ Scribed by Yasuyoshi Watanabe; Motokazu Fujiwara; Osamu Hayaishi; Tomio Takeuchi; Hamao Umezawa


Book ID
119406580
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
311 KB
Volume
85
Category
Article
ISSN
0006-291X

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## Abstract The first and rateโ€limiting step of the kynurenine pathway, in which tryptophan (Trp) is converted to __N__โ€formylkynurenine is catalyzed by two hemeโ€containing proteins, Indoleamine 2,3โ€dioxygenase (IDO), and Tryptophan 2,3โ€dioxygenase (TDO). In mammals, TDO is found exclusively in liv