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Comparative Studies of Human Indoleamine 2,3-Dioxygenase (IDO) and Tryptophan Dioxygenase (TDO)

✍ Scribed by Yeh, Syun-Ru; Lewis-Ballester, Ariel; Karkashon, Shay

Book ID
122241744
Publisher
Biophysical Society
Year
2012
Tongue
English
Weight
38 KB
Volume
102
Category
Article
ISSN
0006-3495

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## Abstract The first and rate‐limiting step of the kynurenine pathway, in which tryptophan (Trp) is converted to __N__‐formylkynurenine is catalyzed by two heme‐containing proteins, Indoleamine 2,3‐dioxygenase (IDO), and Tryptophan 2,3‐dioxygenase (TDO). In mammals, TDO is found exclusively in liv