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Human Tryptophan Dioxygenase: A Comparison to Indoleamine 2,3-Dioxygenase

โœ Scribed by Batabyal, Dipanwita; Yeh, Syun-Ru

Book ID
126262457
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
748 KB
Volume
129
Category
Article
ISSN
0002-7863

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## Abstract The first and rateโ€limiting step of the kynurenine pathway, in which tryptophan (Trp) is converted to __N__โ€formylkynurenine is catalyzed by two hemeโ€containing proteins, Indoleamine 2,3โ€dioxygenase (IDO), and Tryptophan 2,3โ€dioxygenase (TDO). In mammals, TDO is found exclusively in liv