Substrate stereo-specificity in tryptoph
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Luciana Capece; Mehrnoosh Arrar; Adrian E. Roitberg; Syun-Ru Yeh; Marcelo A. Mar
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Article
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2010
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John Wiley and Sons
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English
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## Abstract The first and rateโlimiting step of the kynurenine pathway, in which tryptophan (Trp) is converted to __N__โformylkynurenine is catalyzed by two hemeโcontaining proteins, Indoleamine 2,3โdioxygenase (IDO), and Tryptophan 2,3โdioxygenase (TDO). In mammals, TDO is found exclusively in liv