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Substrate Stereoselectivity of Human Indoleamine 2,3-Dioxygenase

โœ Scribed by Lewis-Ballester, Ariel; Yeh, Syun- Ru


Book ID
122160261
Publisher
Biophysical Society
Year
2009
Tongue
English
Weight
40 KB
Volume
96
Category
Article
ISSN
0006-3495

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## Abstract The first and rateโ€limiting step of the kynurenine pathway, in which tryptophan (Trp) is converted to __N__โ€formylkynurenine is catalyzed by two hemeโ€containing proteins, Indoleamine 2,3โ€dioxygenase (IDO), and Tryptophan 2,3โ€dioxygenase (TDO). In mammals, TDO is found exclusively in liv