Interplay Between Ligand and Substrate Binding in Human Indoleamine 2,3-Dioxygenase
✍ Scribed by Yeh, Syun-Ru; Lu, Changyuan; Lin, Yu
- Book ID
- 122307516
- Publisher
- Biophysical Society
- Year
- 2011
- Tongue
- English
- Weight
- 59 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0006-3495
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## Abstract Human indoleamine 2,3‐dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of L‐tryptophan (L‐Trp) and other indoleamine derivatives. Its activity follows typical Michaelis–Menten behavior only for L‐Trp concentrations up to 50 μM; a further increase in the c
## Abstract The first and rate‐limiting step of the kynurenine pathway, in which tryptophan (Trp) is converted to __N__‐formylkynurenine is catalyzed by two heme‐containing proteins, Indoleamine 2,3‐dioxygenase (IDO), and Tryptophan 2,3‐dioxygenase (TDO). In mammals, TDO is found exclusively in liv