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Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS

✍ Scribed by Seong-Ho Koh; Youngchul Kim; Hyun Y. Kim; Sejin Hwang; Chang Ho Lee; Seung H. Kim


Book ID
116459125
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
640 KB
Volume
205
Category
Article
ISSN
0014-4886

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## Abstract Glutamate excitotoxicity is strongly implicated as a major contributing factor in motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Excitotoxicity results from elevated intracellular calcium ion (Ca^2+^) levels, which in turn recruit cell death signaling pathways. Recent