𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS

✍ Scribed by Raoul, Cédric; Abbas-Terki, Toufik; Bensadoun, Jean-Charles; Guillot, Sandrine; Haase, Georg; Szulc, Jolanta; Henderson, Christopher E; Aebischer, Patrick


Book ID
109932430
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
592 KB
Volume
11
Category
Article
ISSN
1078-8956

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Antisense peptide nucleic acid targeting
✍ Alan Rembach; Bradley J. Turner; Stephen Bruce; Irwin K. Cheah; Rachel L. Scott; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 344 KB

## Abstract Glutamate excitotoxicity is strongly implicated as a major contributing factor in motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Excitotoxicity results from elevated intracellular calcium ion (Ca^2+^) levels, which in turn recruit cell death signaling pathways. Recent