Antisense peptide nucleic acid targeting
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Alan Rembach; Bradley J. Turner; Stephen Bruce; Irwin K. Cheah; Rachel L. Scott;
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Article
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2004
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John Wiley and Sons
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English
⚖ 344 KB
## Abstract Glutamate excitotoxicity is strongly implicated as a major contributing factor in motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Excitotoxicity results from elevated intracellular calcium ion (Ca^2+^) levels, which in turn recruit cell death signaling pathways. Recent