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Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1G93A mouse model of ALS

✍ Scribed by Bernadett Kalmar; Sergey Novoselov; Anna Gray; Michael E. Cheetham; Boris Margulis; Linda Greensmith


Book ID
111181056
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
688 KB
Volume
107
Category
Article
ISSN
0022-3042

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## Abstract Glutamate excitotoxicity is strongly implicated as a major contributing factor in motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Excitotoxicity results from elevated intracellular calcium ion (Ca^2+^) levels, which in turn recruit cell death signaling pathways. Recent