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Effect of Sex on Lifespan, Disease Progression, and the Response to Methionine Sulfoximine in the SOD1 G93A Mouse Model for ALS

โœ Scribed by Bame, Monica; Pentiak, Patricia A.; Needleman, Richard; Brusilow, William S.A.


Book ID
119241614
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
1008 KB
Volume
9
Category
Article
ISSN
1550-8579

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## Abstract Glutamate excitotoxicity is strongly implicated as a major contributing factor in motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Excitotoxicity results from elevated intracellular calcium ion (Ca^2+^) levels, which in turn recruit cell death signaling pathways. Recent