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Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS

✍ Scribed by Guillermo M. Alexander; Kirsten L. Erwin; Nathaniel Byers; Jeffrey S. Deitch; Brian J. Augelli; Elizabeth P. Blankenhorn; Terry D. Heiman-Patterson


Book ID
116753147
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
430 KB
Volume
130
Category
Article
ISSN
0169-328X

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The recent development of a rat model of amyotrophic lateral sclerosis (ALS) in which the rats harbor a mutated human SOD1 (G93A) gene has greatly expanded the range of potential experiments, because the rats' large size permits biochemical analyses and therapeutic trials, such as the intrathecal in