Degeneration of respiratory motor neurons in the SOD1 G93A transgenic rat model of ALS
✍ Scribed by Jerònia Lladó; Christine Haenggeli; Andrea Pardo; Victor Wong; Leah Benson; Carol Coccia; Jeffrey D. Rothstein; Jeremy M. Shefner; Nicholas J. Maragakis
- Book ID
- 113811882
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 808 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0969-9961
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The recent development of a rat model of amyotrophic lateral sclerosis (ALS) in which the rats harbor a mutated human SOD1 (G93A) gene has greatly expanded the range of potential experiments, because the rats' large size permits biochemical analyses and therapeutic trials, such as the intrathecal in
## Abstract Amyotrophic lateral sclerosis (ALS) is a common form of motor neuron disease (MND) that involves both upper and lower nervous systems. In the SOD1^G93A G1H^ transgenic mouse, a widely used animal model of human ALS, a significant pathology is linked to the degeneration of lower motor ne