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Mislocalization of TDP-43 in the G93A mutant SOD1 transgenic mouse model of ALS

โœ Scribed by Xiaoyang Shan; David Vocadlo; Charles Krieger


Book ID
116771368
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
504 KB
Volume
458
Category
Article
ISSN
0304-3940

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The recent development of a rat model of amyotrophic lateral sclerosis (ALS) in which the rats harbor a mutated human SOD1 (G93A) gene has greatly expanded the range of potential experiments, because the rats' large size permits biochemical analyses and therapeutic trials, such as the intrathecal in