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Influence of midbrain raphe lesion on some pharmacological and biochemical effects of apomorphine in rats

✍ Scribed by Maria Grabowska

Publisher
Springer
Year
1974
Tongue
English
Weight
630 KB
Volume
39
Category
Article
ISSN
0033-3158

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Two different techniques were employed to measure morphine analgesia, the hot-plate and the tail compression. An intraventricular injection of 6-hydroxydopamine, which produced a marked decrease of brain noradrenaline and dopamine, strongly potentiated the analgesic effect of morphine. The lesion

Effect of midbrain raphe lesion on the a
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The antinociceptive action of several analgesics was studied by two methods: the hot-plate and the tail compression tests. Lesions of the midbrain raphe, which produce a marked depletion of serotonin in the forebrain, antagonize the analgesic effect of morphine but not that of methadone, meperidine