𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of 6-hydroxydopamine, 5,6-dihydroxytryptamine and raphe lesions on the antinociceptive actions of morphine in rats

✍ Scribed by J. BlÄsig; K. Reinhold; A. Herz

Publisher
Springer
Year
1973
Tongue
English
Weight
484 KB
Volume
31
Category
Article
ISSN
0033-3158

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Effect of midbrain raphe lesion on the a
Effect of midbrain raphe lesion on the antinociceptive action of morphine and other analgesics in rats
✍ R. Samanin; D. Ghezzi; C. Mauron; L. Valzelli 📂 Article 📅 1973 🏛 Springer 🌐 English ⚖ 267 KB

The antinociceptive action of several analgesics was studied by two methods: the hot-plate and the tail compression tests. Lesions of the midbrain raphe, which produce a marked depletion of serotonin in the forebrain, antagonize the analgesic effect of morphine but not that of methadone, meperidine

Effects of intraventriculary injected 6-
Effects of intraventriculary injected 6-OH dopamine or midbrain raphe lesion on morphine analgesia in rats
✍ R. Samanin; S. Bernasconi 📂 Article 📅 1972 🏛 Springer 🌐 English ⚖ 399 KB

Two different techniques were employed to measure morphine analgesia, the hot-plate and the tail compression. An intraventricular injection of 6-hydroxydopamine, which produced a marked decrease of brain noradrenaline and dopamine, strongly potentiated the analgesic effect of morphine. The lesion

Behavioral and electrophysiological effe
Behavioral and electrophysiological effects of 5-HT in globus pallidus of 6-hydroxydopamine lesioned rats
✍ Shu-Jing Zhang; Hua Wang; Yan Xue; Wing-Ho Yung; Lei Chen 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 456 KB

## Abstract Anatomical studies have shown that the globus pallidus receives abundant 5‐hydroxytryptamine (5‐HT) innervations from raphe nuclei. 5‐HT may occupy an important position in the modulation of motor function through its affect on the activity of globus pallidus. In the present study, intr

Effects of neonatal treatment with 5,7-d
Effects of neonatal treatment with 5,7-dihydroxytryptamine or 6-hydroxydopamine on the ontogenetic development of the audiogenic immobility reaction in the rat
✍ Ernest Hård; Sven Ahlenius; Jörgen Engel 📂 Article 📅 1983 🏛 Springer 🌐 English ⚖ 722 KB

The ontogenetic development of the audiogenic immobility reaction (freezing) was studied in rats given intracisternal injections of the neurotoxins 5,7-dihydroxytryptamine (5,7-DHT), 25 gg, or 6-hydroxydopamine (6-OHDA), 100 gg, neonatally (Day 1). The duration of the freezing response was strongly

Pharmacokinetics and pharmacodynamics of
Pharmacokinetics and pharmacodynamics of morphine-3-glucuronide in rats and its influence on the antinociceptive effect of morphine
✍ Marianne Ekblom; Marie Gårdmark; Margareta Hammarlund-Udenaes 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 555 KB

In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,