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Effects of intraventriculary injected 6-OH dopamine or midbrain raphe lesion on morphine analgesia in rats

✍ Scribed by R. Samanin; S. Bernasconi

Publisher: Springer
Year: 1972
Tongue: English
Weight: 399 KB
Volume: 25
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00423195

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✦ Synopsis

Two different techniques were employed to measure morphine analgesia, the hot-plate and the tail compression.

An intraventricular injection of 6-hydroxydopamine, which produced a marked decrease of brain noradrenaline and dopamine, strongly potentiated the analgesic effect of morphine.

The lesion of midbrain raphe, which lowers forebrain serotonin, antagonized morphine analgesia.

5-Hydroxytryptophan restored serotonin levels and the analgesic effect of morphine in midbrain raphe lesioned rats.

The role of brain serotonin and catecholamines on morphine analgesia is discussed.

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