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The effect of raphé nuclei lesions on striatal tyramine concentration and dopamine turnover in the rat

✍ Scribed by A. V. Juorio; A. J. Greenshaw


Publisher
Springer
Year
1986
Tongue
English
Weight
339 KB
Volume
11
Category
Article
ISSN
0364-3190

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✍ R. Samanin; D. Ghezzi; C. Mauron; L. Valzelli 📂 Article 📅 1973 🏛 Springer 🌐 English ⚖ 267 KB

The antinociceptive action of several analgesics was studied by two methods: the hot-plate and the tail compression tests. Lesions of the midbrain raphe, which produce a marked depletion of serotonin in the forebrain, antagonize the analgesic effect of morphine but not that of methadone, meperidine