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Influence of [2H]-labelled acetic acid as solvent in the synthesis of [2H]-labelled perhexiline

✍ Scribed by Søren Christian Schou

Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
124 KB
Volume
53
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Preparation of deuterium‐labelled perhexiline from an unsaturated analogue was performed via reduction with deuterium gas and PtO~2~ in acetic acid. Low incorporation was observed when using acetic acid as solvent (most abundant mass peak was M), but when changing the solvent to deuterium‐labelled acetic acid, e.g. acetic acid‐OD or acetic acid‐d~4~, a higher incorporation was observed (most abundant mass peak was M). Using hydrogen gas instead of deuterium gas with deuterium‐labelled acetic acid, high levels of deuterium incorporation were observed (most abundant mass peak was M). An attempt to reduce a precursor with a fully deuterated pyridine to obtain perhexiline with a higher content of deuterium failed. Copyright © 2009 John Wiley & Sons, Ltd.

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