𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis, 1H-NMR and mass spectra of 2-2H-, 2,3-2H2- and 2,2-2H2-labelled short chain carboxylic acids

✍ Scribed by David G. Hine; Yasuyuki Ikeda; Kay Tanaka

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
437 KB
Volume
22
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

2‐^2^H, 2,3‐^2^H~2~ and 2,2‐^2^H~2~ ‐ short chain carboxylic acids were synthesized. Monodeuteration at the 2‐position of the carboxylic acids was achieved via decarboxylation of the corresponding carboxyldeuterated 2‐alkylmalonic acids. 2,3‐Dideuteration was achieved via catalytic deuteration of the corresponding 2,3‐ unsaturated carboxylic acids with sodium borodeuteride. 2,2‐Dideuteration was achieved via repeated base catalyzed exchange reactions of the carboxylate sodium salts in sodium deuteroxide/deuterium oxide solution. Proton nuclear magnetic resonance and mass spectra of the obtained products are presented.

📜 SIMILAR VOLUMES

Synthesis of (2R,S)- [2-2H] and [2,3-2H]
Synthesis of (2R,S)- [2-2H] and [2,3-2H] tryptophan
✍ Enzo Santaniello; Manuela Ravasi; Franca Astori 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 278 KB 👁 1 views

## Abstract α‐Deuterated tryptophan was prepared either by exchange of the α‐hydrogen of tryptophan or by hydrolysis and decarboxylation of ethyl 2‐formamido‐2‐carbethoxy‐3‐indole propionate, followed by treatment with CH~3~COO^2^H. α,β‐Dideuterated tryptophan was in turn synthetized from ethyl‐α‐a

The syntheses of 4-aminobutanoic acid-2,
The syntheses of 4-aminobutanoic acid-2,2-2H2 and -4,4-2H2 and progabide-2,2-2H2 and -4,4-2H2
✍ Bruce Davis 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 293 KB

4-Aminobutanoic a ~i d -2 , 2 -~H z and -4,4-2H2 were synthesized i n h i g h y i e l d w i t h h i g h deuterium incorporation, and then converted i n t o the corresponding deuterium-labelled a n t i -convul sant drug, progabi de, by means o f a t r a n s i m i n a t i on reaction.

Synthesis of malondialdehyde-1-2H and ma
Synthesis of malondialdehyde-1-2H and malondialdehyde-1,3-2H2
✍ Ashis K. Basu; Lawrence J. Marnett 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 French ⚖ 215 KB 👁 1 views

Two synthetic routes for deuterium labelling of 1,1,3,3-tetraethoxypropane, the precursor of the ubiquitous natural compound malondialdehyde, are described. In one scheme, deuterium is inc.orporated in ethyl vin 1 ether by metalation ing with $,,,. The conversion of the deuterated ether to monodeute

The synthesis of [2-3H2] taurine and [2-
The synthesis of [2-3H2] taurine and [2-3H2] hypotarine
✍ J. H. Fellman 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 146 KB 👁 1 views

## Abstract The synthesis of [2‐^3^H~2~]‐2‐aminoethanesulfonate [2‐^3^H]‐taurine by the reduction of cyanomethanesulfonic acid with tritium gas is described. The conversion of [2‐^3^H]‐taurine and its ^14^C and ^35^S isotopic forms to 2‐aminoethanesulfinate (hypotaurine) was accomplished by convert

Synthesis of Z- and E-[2,3-2H2] and [2,3
Synthesis of Z- and E-[2,3-2H2] and [2,3-3H2]-1,1-dichloro-2,3- diphenylcyclopropane (2H- and 3H-analog II and its trans isomer)
✍ Billy W. Day; Sastry S. Jonnalagadda 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 338 KB

## Abstract ^2^H and ^3^H labeled __Z__‐ and __E__‐1,1‐dichloro‐2,3‐diphenylcyclopropane (1 and 2) were synthesized starting from NaB^2^H~4~ and NaB^3^H~4~ reduction of benzil. The resulting glycols were transformed to the 1,2‐labeled Z‐ and E‐stilbenes by thermolysis of their cyclic thionocarbonat