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The syntheses of 4-aminobutanoic acid-2,2-2H2 and -4,4-2H2 and progabide-2,2-2H2 and -4,4-2H2

✍ Scribed by Bruce Davis

Publisher
John Wiley and Sons
Year
1987
Tongue
French
Weight
293 KB
Volume
24
Category
Article
ISSN
0022-2135

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✦ Synopsis

4-Aminobutanoic a ~i d -2 , 2 -~H z and -4,4-2H2 were synthesized i n h i g h y i e l d w i t h h i g h deuterium incorporation, and then converted i n t o the corresponding deuterium-labelled a n t i -convul sant drug, progabi de, by means o f a t r a n s i m i n a t i on reaction.

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## Abstract The four deuteriated 4‐phenylbutyric [2,3‐^2^H~2~]‐, [4,4‐^2^H~2~]‐, [2,3,4,4‐^2^H~4~]‐, and [2,2,3,3,4,4‐^2^H~6~]‐acids have been synthesized in high isotopic purity by utilizing crossed Kolbe electrolysis of methyl hydrogen [^2^H~0~]‐, [2,3‐^2^H~2~], and [2,3,3,3‐^2^H~4~]‐succinates a