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Preparation of 4-phenylbutyric [2,3-2H2]-, [4,4-2H2]-, [2,3,4,4-2H4]-, and [2,2,3,3,4,4-2H6]-acids by use of crossed kolbe electrolysis as a key reaction

✍ Scribed by Masashi Tashiro; Hirohisa Tsuzuki; Hideyuki Goto; Shoji Ogasahara; Shuntaro Mataka

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
301 KB
Volume
29
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The four deuteriated 4‐phenylbutyric [2,3‐^2^H~2~]‐, [4,4‐^2^H~2~]‐, [2,3,4,4‐^2^H~4~]‐, and [2,2,3,3,4,4‐^2^H~6~]‐acids have been synthesized in high isotopic purity by utilizing crossed Kolbe electrolysis of methyl hydrogen [^2^H~0~]‐, [2,3‐^2^H~2~], and [2,3,3,3‐^2^H~4~]‐succinates and phenyl acetic [^2^H~0~] and [^2^H~2~]‐acids as a key reaction.

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